青娥丸治疗骨质疏松及主要活性成分研究进展
摘 要 青娥丸系补肾壮骨名方，以杜仲为君药、补骨脂为臣药，常用于治疗肾虚腰痛，起坐不利，膝软乏力等。当前，随着人口老龄化现象的发生，骨质疏松症的发病率也在不断上升，骨质疏松症的防治成为备受关注的问题。女性由于绝经后雌激素水平下降，骨质加速流失，骨质疏松发病率明显增加。因此研究青娥丸治疗绝经后骨质疏松的临床疗效和作用机理，以及青娥丸中主要组方药材杜仲、补骨脂的抗骨质疏松活性成分，以便于从单体成分入手揭示复方的炮制机理，阐明化学成分的变化与药理药效变化的关系。对延缓绝经后妇女骨量减少，防治骨质疏松和提高中老年女性的生活质量有重要的临床意义。
关键字 青娥丸；骨质疏松；杜仲；补骨脂
Advances in researchofQinge pillin the treatmentof osteoporosisand main active ingredients
AbstractQinge Pill is a famous prescription for tonifying kidney and strengthening bone,which is Commonly used to treat kidney deficiency, low back pain, bad sitting up,weak knee and so on. At present, with the occurrence of population aging, the incidence of osteoporosis is also rising, and the prevention and treatment of osteoporosis has become a concern. As womens estrogen levels decrease after menopause, bone mass is accelerated and the incidence of osteoporosis is significantly increased. Therefore, to study the clinical efficacy and mechanism of Qinge Pill in the treatment of postmenopausal osteoporosis, and the anti-osteoporotic active ingredients of Eucommia ulmoides and Psoralea corylifolia have important clinical significance in delaying postmenopausal womens bone loss, preventing and treating osteoporosis and improving the quality of life of elderly women.
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