我院药品不良反应情况分析文献综述

 2023-01-05 20:31:24

【摘要】目的 总结我院2010-2014年药品不良反应(ADR)监测情况,促进临床安全、合理用药。方法 采用描述性研究方法,对我院近年来上报的536例疑似药品不良反应,分别从患者的一般情况,药物种类、用药途径、临床表现等方面进行统计、分析与评价。结果 536例药品不良反应监测报告中,涉及208种药品,由抗菌药物引起的疑似药品不良反应最多,共221例(占41.23%);由中药制剂引起的疑似药品不良反应其次,有83例(占15.5%);由静脉滴注用药途径引起疑似药品不良反应最多见,有304例(占56.72%);发生ADR的患者中女性多于男性(1.82:1),60岁以上患者发生ADR多于其他年龄段; ADR的临床表现以皮肤及其附件损害最多见,占33.02%。结论 我院抗菌药物静脉注射引发的不良反应较多,应予以特别关注。

【关键词】药品不良反应,抗菌药物

Analysis of 536 ADR Cases Occurred during 2010 to 2014 in Our Hospital

Ding duo

(Department of Pharmacy, Yangpu district central hospital 200090)

[ABSTRACT] Objective: To investigate the occurrence of adverse drug reactions (ADR) during 2010 to 2014 in our hospital, so as to enhance the hospital drug use reasonable level in clinic. Methods: 536 ADR cases were collected during 2010 to 2014 in our hospital were analyzed in respect of the patientrsquo;s age and sex, drug species, route of administration and clinical manifestation etc. Results: 208drugs species were involved in 536 ADR cases.221 cases (41.23%)were related to anti-infective, it was the mainly ADR; the next was the Chinese patent medcine (83 cases,15.5%); 304 cases(56.72%) were induced by intravenous drop infusion; the ADR cases of female were more than male, and the proportion was 1.82:1 ; the ADR ration of patients that over 60 years old was more than other age groups; and clinical manifested as lesion of skin and its accessories (33.02%). Conclusion: the ADR cases of the anti-infective by intravenous drop infusion was more in our hospital, this situation should be emphasized and give more attention.

[KEY WORDS] adverse drug reaction; anti-infective drug

【关键词】药品不良反应,抗菌药物

药品不良反应(ADR)是指合格的药品在正常的用法、用量情况下出现的与用药目的无关的有害反应,它包括药品的副作用、毒性反应、依赖性、特异质反应等。近年来,随着众多新药的不断上市,合并用药的现象增多,药品在发挥治疗作用的同时,ADR发生率也随着增加。为了总结上海市杨浦区中心医院2010到2014年ADR监测情况,寻找发生ADR的一般规律,保障临床安全、合理用药,作者对本院五年来上报的536例ADR病例报告进行了分析与评价,现报告如下。

1 资料和方法

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