抑郁症临床用药研究进展
摘 要:抑郁症( depression)是以显著而持久的心境低落、思维迟缓、认知功能损害、意志活动减退和躯体症状为主要临床特征的一类心境障碍。它是一种严重的精神疾病,对社会危害极大。目前,抑郁症的发病机制尚不明确,但科学家们发现了几种可信的假说,并依据这些假说开发出了几类抗抑郁的临床药物。本文总结了目前临床上常用的抗抑郁的几类药物,分析其所依据的发病机制和优缺点。进而提出抗抑郁药物的合理用药。
关键词: 抑郁症;临床药物;分类;优缺点;合理用药
[Abstract] Depression is a significant and lasting mental retardation, slow thinking, cognitive impairment, decreased will and physical symptoms as the main clinical features of a class of mood disorders. It is a serious mental illness, great harm to society. At present, the pathogenesis of depression is not clear, but the scientists found several credible hypotheses, and based on these hypotheses developed several types of antidepressant clinical drugs. This article summarizes the current commonly used antidepressant several types of drugs, analysis of its pathogenesis and advantages and disadvantages. And then put forward the rational use of antidepressants.
[Key words] Depression; clinical drugs; classification; advantages and disadvantages; rational drug use
抑郁症状( depression) 为心境障碍的一种临床症状,它以显著而持久的心境低落、思维迟缓、认知功能损害、意志活动减退和躯体症状为主要临床特征的一类心境障碍。WHO预测 2020年抑郁症将成为全球第二位医疗疾患。
关于抑郁症的发病机制目前尚未有明确的解释,但经过科学家们的不断努力,截至目前已总结出几种关于抑郁症发病机制的可信假说,为抑郁症治疗的临床用药的开发提供了依据。本文以抑郁症的发病机制为依据,详细介绍目前临床上经常应用的几类抗抑郁药物及其各自的优点和不良反应。
1、 抗抑郁药物分类
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